CHAPTER 11 - Monitoring Sleep and Arousal in Zebrafish
نویسندگان
چکیده
Zebrafish has emerged in the past 5 years as a model for the study of sleep and wake behaviors. Experimental evidence has shown that periods of behavioral quiescence in zebrafish larvae and adults are sleep-like states, as these rest bouts are regulated by the circadian cycle, are associated with decreases in arousal, and are increased following rest deprivation. Furthermore, zebrafish share with mammals a hypocretin/orexin system that promotes wakefulness, and drugs that alter mammalian sleep have similar effects on zebrafish rest. In this chapter, we review the zebrafish sleep literature and describe a long-term, high-throughput monitoring system for observing sleep and wake behaviors in larval zebrafish. METHODS IN CELL BIOLOGY, VOL. 100 978-0-12-384892-5 Copyright ! 2010 Elsevier Inc. All rights reserved. 281 DOI: 10.1016/B978-0-12-384892-5.00011-6
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